Systemic Sclerosis

An Update

Uwe-Frithjof Haustein, MD, PhD


Lab Med. 2011;42(9):562-572. 

In This Article

Vasoactive Medication

Continuous intravenous infusion of prostacyclin (PGI2)-like substances (iloprost, epoprostenol) decreases the frequency and severity of Raynaud's attacks and induces healing of digital ulcers.[96] Endothelin-1 rec antagonists such as bosentan or sitaxsentan are helpful in prevention as well as healing of digital ulcers and in controlling PHT (grade 2 to 4). They improve exercise capacity, functional class and some hemodynamic measures in PHT. In addition, sildenafil, a phosphodiesterase inhibitor, is also effective in the treatment of PHT and digital ulcers.[97]


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