Systemic Sclerosis

An Update

Uwe-Frithjof Haustein, MD, PhD

Disclosures

Lab Med. 2011;42(9):562-572. 

In This Article

Endothelial Cell Apoptosis

Endothelial cell apoptosis may also be a primary event in SSc.[42] It may be related to viral infection, including cytomegalovirus (CMV), in view of the increased levels of anti-CMV antibodies measured in SSc and the remarkable similarities between CMV vasculopathies and SSc vascular disease.[43] On the other hand, endothelial apoptosis may be related to immune reactions, to antiendothelial antibodies, to environmental factors, and/or reperfusion injury.[44]

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