Implications of Blood Type for Ovarian Reserve

Edward J. Nejat; Sangita Jindal; Dara Berger; Erkan Buyuk; Maria Lalioti; Lubna Pal


Hum Reprod. 2011;26(9):2513-2517. 

In This Article


Continuous data are presented as median (inter-quartile range, IQR), and categorical data are presented as percentage (%). Informative data were available for 544 women ages ≤45 (median age 35, IQR 30–39). Prevalence of blood types according to the order of frequency is presented in Table I. Participants' ages, ovarian reserve parameters and representation of blood types O, A and AB were comparable between the two study sites (P> 0.20); blood type B, however, was more commonly encountered in participants enrolled at study site 2 (18 versus 13%, P= 0.07).

A relationship between blood types O and blood groups bearing the A antigen (blood types A or AB) with ovarian reserve parameters was observed (Table II). Univariate analyses identified a significantly higher representation of blood type O among patients with FSH > 10 mIU/ml (OR 2.14, 95% CI 1.22–3.80, P= 0.004); this association was further magnified for those with FSH > 12 mIU/ml (OR 2.44, 95% CI 1.22–5.04, P= 0.006). Conversely, a significantly higher representation of the A antigen (blood types A or AB) was observed among those with normal ovarian reserve, i.e. FSH ≤ 10 mIU/ml, compared with those with DOR (41 versus 26%, P= 0.02).

After adjusting for age, blood type B and study site, patients with blood type O were twice as likely to exhibit FSH > 10 mIU/ml compared with those with A bearing blood types (either A or AB; Table III) and three times as likely to manifest FSH > 12 mIU/ml (OR 3.48, 95% CI 1.46–7.32, P= 0.004). Goodness of fit for the adjusted logistic regression models was 0.74 and 0.78 for FSH thresholds of 10 and 12, respectively. Conversely, women with the A blood group antigen (blood types A or AB) were significantly less likely to manifest FSH > 10 mIU/ml compared with those with blood type O (Table III). The B blood group antigen failed to exhibit any relationship with ovarian reserve as reflected by baseline FSH (either taken as a continuous variable or categorized based on specified thresholds, P> 0.05).


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