Cutaneous Reactions to Transdermal Therapeutic Systems

Andrea Bershow; Erin Warshaw

Disclosures

Dermatitis. 2011;22(4) 

In This Article

Abstract and Introduction

Abstract

Transdermal therapeutic systems (TTSs) are commonly used to treat many diverse medical conditions. There are several advantages to this form of drug delivery; however, adverse cutaneous reactions are common. This review article provides an update on skin reactions due to TTSs containing medications newly available in TTS form, including buprenorphine, diclofenac, lidocaine, oxybutynin, rotigotine, methylphenidate, rivastigmine, teriparatide, and nicardipine.

Introduction

Transdermal drug delivery systems are increasingly prescribed instead of oral formulations because of several potential advantages, including convenience and increased patient compliance. Another benefit is the avoidance of first-pass metabolism and fluctuating plasma concentrations. Most patients experience fewer side effects with transdermal drug delivery systems than with oral delivery of drugs; however, skin reactions can have a negative impact on compliance. Although skin reactions are common, it is possible to minimize their incidence and to manage their signs and symptoms.[1]

Nineteen drugs are currently available in transdermal therapeutic systems (TTSs) in the United States, including lidocaine, nitroglycerin, nicardipine, nicotine, scopolamine, estradiol, testosterone, clonidine, oxybutynin, ketoprofen, diclofenac, fentanyl, and buprenorphine.[2,3] Several others are in clinical trials.

Our group published a comprehensive review of skin reactions to TTSs in 2006, covering reactions to TTSs containing nitroglycerin, nicotine, scopolamine, estradiol, testosterone, clonidine, and fentanyl.[1] The purpose of this review is to provide an update on reactions associated with medications that are newly available in TTS form, including buprenorphine, diclofenac, lidocaine, oxybutynin, rotigotine, methylphenidate, rivastigmine, teriparatide, and nicardipine.

Comments

3090D553-9492-4563-8681-AD288FA52ACE
Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as:

processing....