Clinical and Immunological Features of Celiac Disease in Patients With Type 1 Diabetes Mellitus

Umberto Volta; Francesco Tovoli; Giacomo Caio


Expert Rev Gastroenterol Hepatol. 2011;5(4):479-487. 

In This Article

CD in Relatives of T1DM Patients

It is well established that the finding of CD in first degree relatives of T1DM patients is significantly more frequent than in the general population, with a prevalence ranging from 4.8 to 6%.[54,55] The risk of developing CD for first-degree relatives of T1DM increases in those with another associated autoimmune disorder. Based on these data, it is advisable to also perform serological screening in first-degree relatives of T1DM. It has not yet been established whether tTGA-negative first-degree relatives of T1DM need to be followed up by serological screening. This option also remains controversial in first-degree relatives of CD patients without T1DM.[56]


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