Nutritional and Metabolic Status of Children With Autism vs. Neurotypical Children, and the Association With Autism Severity

James B Adams; Tapan Audhya; Sharon McDonough-Means; Robert A Rubin; David Quig; Elizabeth Geis; Eva Gehn; Melissa Loresto; Jessica Mitchell; Sharon Atwood; Suzanne Barnhouse; Wondra Lee


Nutr Metab. 2011;8(41) 

In This Article

Limitations of This Study

1) The diagnosis of an autism spectrum disorder by a qualified medical professional was verified in writing, but there no additional verification. Similarly, for the neurotypical children, no additional verification was made beyond the parental report.

2) The sample size of 55 children with ASD and 44 neurotypical children was large enough to observe many significant differences between the two groups, but some differences were only marginally or possibly significant - another study, preferably with larger number of participants, is needed to verify some of the observations.

3) Although several functional tests of need for vitamins were conducted, several more could have been added, but there were limitations on the total amount of tests that could be done with the blood that was drawn.

4) Medication effects: 45% of the children with autism were taking one or more medications (see Table 1), but those medications appear to have had little effect on the study results (see Medication Effects in the Results section).

5) Dietary effects: 16% of the children with autism were on special diets (see Table 1), which might have had some effect on the results.

6) All the study participants were from Arizona, so the results for this region may be somewhat different from other parts of the US or the world.


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