Myths and Truths of Growth Hormone and Testosterone Therapy in Heart Failure

Cam T Nguyen; Alistair Aaronson; Ryan P Morrissey; Megha Agarwal; Robert D Willix; Ernst R Schwarz


Expert Rev Cardiovasc Ther. 2011;9(6):711-720. 

In This Article

Animal Models

In some animal models, GH or IGF-1 have both demonstrated beneficial effects on cardiac function, peripheral resistance and survival.[34–36] Yang et al. demonstrated that GH treatment in rats with LV dysfunction enhanced myocardial contractility, CO and stroke volume.[35] Furthermore, there was a decrease in LV end-diastolic pressure and peripheral vascular resistance. Duerr et al. demonstrated an augmented hypertrophic response of viable myocardium and cardiac function in rats postmyocardial infarction when treated with recombinant IGF-1.[36] In the post-infarct rat model, GH resulted in prolonged survival, possibly secondary to enhanced LV function via marked attenuation of cardiomyocyte apoptosis and pathologic interstitial remodeling in the surviving myocardium.[37] A similar retardation of cardiomyocyte apoptosis has been shown in ethanol-induced apoptosis of the myocardium with administration of IGF-1.[14]