Pharmacotherapy for Obesity

A Field in Crisis?

Wiebke Fenske; Jennifer Parker; Stephen R Bloom


Expert Rev Endocrinol Metab. 2011;6(4):563-577. 

In This Article

Pharmacotherapy of Obesity

Treatments designed to induce weight loss focus on reducing energy intake (by decreasing food absorption or by decreasing appetite), increasing energy expenditure or a combination of both effects. Safe drugs that target fat storage mechanisms have not so far been identified. There are four broad categories into which current and future agents can be divided: peripherally acting agents reducing the efficiency of digestion; agents modifying the homeostatic regulation of food intake and energy expenditure, which can be further divided into those with central and peripheral actions; and agents that act to inhibit food intake by acting on the brain's reward centers.


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