Systematic Review

The Epidemiology and Natural History of Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis in Adults

G. Vernon; A. Baranova; Z. M. Younossi


Aliment Pharmacol Ther. 2011;34(3):274-285. 

In This Article

Incidence of NAFLD and NASH

The incidence of NAFLD is underreported and varies wildly (Figure 1). A study based on routine health care of Japanese government employees revealed an overall incidence of non-alcoholic hypertransaminasemia of 31 cases per 1000 person-years.[2] Another Japanese study reported follow-up data on 3147 individuals without NAFLD at baseline; of these, 308 (10%) developed new cases of NAFLD over 414 days.[3] A recent study of an out-patient hepatology clinic in England reported an incidence rate of 29 cases per 100,000 person-years.[4] The clear discrepancy among these rates suggests that accurate global incidence rates for NAFLD require further study.

Figure 1.

Non-alcoholic fatty liver disease incidence in the general population.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as: