Combination Therapy of Biologics With Traditional Agents in Psoriasis

Lyn C. Guenther, MD, FRCPC

Disclosures

Skin Therapy Letter. 2011;16(6) 

In This Article

Combination Therapy With Adalimumab (Humira®)

Calcipotriol + Betamethasone Dipropionate

Adalimumab used in combination with calcipotriol + betamethasone dipropionate (Dovobet®) showed a more rapid and higher PASI 75 response at week 4 (40.7% vs. 32.4%, p=0.021) compared with adalimumab monotherapy.[11] However, at week 16, there was no significant difference in PASI 75 response (64.8% with combination therapy vs. 70.9% with adalimumab monotherapy, p=0.086).

Methotrexate

Adalimumab in combination with methotrexate results in down regulation of more inflammatory markers in psoriatic plaques than monotherapy with either agent.[12] In the ADEPT psoriatic arthritis trial, at week 48, PASI 50, 75, 90, and 100 response rates were greater in the with-methotrexate subgroups (n=29) compared to the adalimumab without methotrexate subgroup (n=40), but only the PASI 50 results were statistically significant (PASI 50 in 83% vs. 55 %, p<0.05).[13]

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