In conclusion, our cross-sectional observation indicated that vitamin C deficiency was prevalent in dialysis patients, and lower plasma vitamin C level was associated with lower serum prealbumin and higher hsCRP concentration which may be closely link to oxidative stress and inflammation in uremia. Further large-scale, long-term interventional clinical trials are required to validate if vitamin C supplementation can reduce inflammatory process and improve outcome of dialysis patients.
The authors declare that they have no competing interests.
KYZ participated in the design of the study, sampling procedure, and drafted the manuscript. LL participated in the design of the study and sampling procedure. XYC participated in the design of the study. JD participated in the design of the study. QMG participated in sampling procedure and performed some statistical analysis. LZ conceived the study, and participated in its design and coordination and performed statistical analysis. All authors read and approved the final manuscript.
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Cite this: Low Levels of Vitamin C in Dialysis Patients is Associated With Decreased Prealbumin and Increased C-reactive Protein - Medscape - May 01, 2011.