Antioxidant and Antiatherogenic Effects of Pomegranate

Stacy L. Haber, Pharm.D; Jamie K. Joy, Pharm.D; Roxanne Largent, Pharm.D


Am J Health Syst Pharm. 2011;68(14):1302-1305. 

In This Article


The studies reviewed found that pomegranate enhanced anti-oxidant activity, reduced oxidant activity, and reduced blood pressure. The studies had mixed results regarding pomegranate's ability to reduce cholesterol levels and CIMT; however, two of the four studies that evaluated these endpoints yielded significant results that favored pomegranate for cholesterol reduction; the other two studies had favorable results that did not reach statistical significance.[4,5,9,11]

Several limitations of the studies reviewed are worth noting. First, the dosages of pomegranate may not have been appropriate to maximize clinically significant benefits, and they varied greatly. Second, some, but not all, of the researchers stated that specific dietary instructions were given to patients, which may have affected the outcomes. Third, some studies used standardized, commercially available pomegranate preparations, while others used freshly squeezed juice. There is likely significant variation between these processes, and commercially prepared juice may have stronger antioxidant effects compared with hand-processed juice.[1] Lastly, many of the studies were of a short duration, so it is unknown if pomegranate would continue to exhibit its effects if used long-term.

A few adverse reactions have been reported with pomegranate, including allergic reactions, and there have also been some reports of clinically relevant drug interactions.


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