Hepatitis G in Children
Hepatitis G (HGV) was originally identified as the result of an investigation of transfusion recipients with mild asymptomatic increase in transaminases. PCR analysis yielded a sequence similar to that of HCV. This virus was named HGV at the time, though it is now referred to has GB virus and is subdivided into 3 distinct genotypes, types A, B, and C. GBV-C was the original HGV and is now recognized to have 5 major genotypes.
Clinically, GBV-C is a nonentity that is not associated with disease. There are no current recommendations for screening.
Interestingly, HIV patients coinfected with GBV have been found to have a reduced mortality rate for reasons that are currently unknown.It is possible that the virus causes an inhibition of HIV replication, or it may simply be a marker for other factors that produce a favorable HIV response.
Medscape Infectious Diseases © 2011
Cite this: Ravi Jhaveri. What's New -- Part 2: Viral Hepatitis in Children - Medscape - Jul 06, 2011.