What's New -- Part 2: Viral Hepatitis in Children

Hepatitis C, D, E, and G in Children

Ravi Jhaveri, MD


July 06, 2011

In This Article

Hepatitis G in Children

Hepatitis G (HGV) was originally identified as the result of an investigation of transfusion recipients with mild asymptomatic increase in transaminases. PCR analysis yielded a sequence similar to that of HCV. This virus was named HGV at the time, though it is now referred to has GB virus and is subdivided into 3 distinct genotypes, types A, B, and C. GBV-C was the original HGV and is now recognized to have 5 major genotypes.[8]

Clinically, GBV-C is a nonentity that is not associated with disease. There are no current recommendations for screening.

Interestingly, HIV patients coinfected with GBV have been found to have a reduced mortality rate for reasons that are currently unknown.[9]It is possible that the virus causes an inhibition of HIV replication, or it may simply be a marker for other factors that produce a favorable HIV response.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.