Proteomics Moves From Expression to Turnover

Update and Future Perspective

Mary K Doherty; Phillip D Whitfield

Disclosures

Expert Rev Proteomics. 2011;8(3):325-334. 

In This Article

Expert Commentary

Proteomics is about more than identifying and quantifying proteins. To truly integrate the discipline with other 'omic' technologies, it is important that methods are found to address the dynamics of the system and how the cell or organism moves from one state to another. This is important for understanding areas as diverse as growth, aging, response to environmental stress and a range of pathologies. A great deal of research has focused on whole-body turnover, which, while extremely valuable, does not address the nuances of the individual cell's ability to adapt to changing circumstances. The landscape has changed considerably over the past 5 years, with new and innovative methods to directly measure individual protein synthesis, degradation and turnover on a global scale. Researchers are also moving from studies solely in cell culture to applied studies in animals and plants. Although the majority of studies still rely on the use of stable isotope-labeled tracers and MS, complementary non-mass spectrometric methods are also emerging.[59]

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