Economic Impact of Venous Thromboembolism After Hip and Knee Arthroplasty

Potential Impact of Rivaroxaban

Richard J Friedman; Nishan Sengupta; Michael Lees


Expert Rev Pharmacoeconomics Outcomes Res. 2011;11(3):299-306. 

In This Article

Duration of Thromboprophylaxis After Total Hip & Knee Arthroplasty

An early recommendation for patients undergoing THA was to extend the use of LMWHs beyond hospital discharge,[13] particularly with the shift towards reduced duration of hospitalization after THA and TKA (mean 3.7 days).[14] More recently, the American College of Chest Physicians (ACCP) guidelines recommend LMWHs, fondaparinux or warfarin for at least 10 days and up to 35 days after THA, and suggest extended thromboprophylaxis up to 35 days after TKA in certain patients.[3] There is increasing evidence that the risk of VTE remains for some time after THA[15,16] and, to a lesser extent, after TKA,[17] and also that extended prophylaxis after surgery may significantly reduce the frequency of DVT.[18–20]


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.