Study (year) |
Patient age, gestation, risk factors and presenting symptoms |
Thrombolytic |
Maternal outcome |
Fetal outcome |
Ref. |
Murugappan et al. (2006) |
37 years of age AA, known pregnancy at 12 weeks Mechanical valve, off anticoagulation L hemiparesis, NIHSS 19 |
IV rtPA |
NIHSS eventually improved to 4 Small intrauterine hematoma |
Elective termination |
[44] |
Murugappan et al. (2006) |
31 years of age, unknown pregnancy at approximately 4 weeks R hemiparesis, expressive aphasia |
IV rtPA |
NIHSS eventually improved to 4 |
Elective termination |
[44] |
Murugappan et al. (2006) |
29 years of age, unknown pregnancy AVR, off anticoagulation L hemiplegia, NIHSS 13 |
IV rtPA |
No improvement, died during subsequent angioplasty owing to arterial dissection |
Maternal demise |
[44] |
Murugappan et al. (2006) |
43 years of age, known pregnancy at 37 weeks AT-III and functional protein C deficiency R hemiparesis, global aphasia, NIHSS 25 |
IV rtPA |
Improved to NIHSS 11; 90 days after event had no residual deficits |
Healthy infant delivered at term via spontaneous vaginal delivery |
[44] |
Murugappan et al. (2006) |
28 years of age, known pregnancy in first trimester Protein C and S deficiencies, PFO, L iliac DVT Vertigo, nausea/vomiting and eventually coma due to basilar occlusion |
IA UK |
Improved Buttock hematoma |
Healthy infant delivered at term |
[44] |
Murugappan et al. (2006) |
25 years of age, known pregnancy in first trimester MVR with endocarditis R hemiparesis, expressive aphasia |
IA UK |
Improved; 4 months later no residual deficits Asymptomatic ICH |
Spontaneous abortion |
[44] |
Murugappan et al. (2006) |
40 years of age, known pregnancy at 6 weeks Polycythemia vera, essential thrombocytosis Nausea/vomiting, papilledema, CN VI palsy due to CVT |
Local UK |
Improved; residual visual field deficit |
Spontaneous abortion (lethal chromosomal abnormalities) |
[44] |
Murugappan et al. (2006) |
21 years of age, known pregnancy at 8 weeks Antiphospholipid antibody syndrome HA, nausea/vomiting, altered mental status, seizures, R hemiparesis due to CVT |
Local UK |
Improved; residual short-term memory deficit Asymptomatic ICH at ventriculostomy site |
Elective termination |
[44] |
Wiese et al. (2006) |
33 years of age, known pregnancy at 13 weeks Mechanical valve, transitioned from warfarin to subcutaneous heparin due to pregnancy R hemiparesis, expressive aphasia, NIHSS 13 |
IV rtPA |
NIHSS eventually improved to 4 |
Healthy infant delivered at term via cesarean section |
[46] |
Dapprich (2002) |
First trimester |
IV rtPA |
Improved |
Healthy infant delivered at term |
[47] |
Elford et al. (2002) |
28 years of age s/p in vitro fertilization, with ovarian hyperstimulation syndrome L hemiplegia, NIHSS 11 (angiogram showed R M1 occlusion) |
IA rtPA |
Improved to NIHSS 3, then worsened and found to have R basal ganglia hemorrhage, ultimately improved |
Healthy infant delivered at term via SVD |
[45] |
Johnson et al. (2005) |
39 years of age with known pregnancy at 37 weeks L hemiplegia, NIHSS 20 (angiogram showed R M1 occlusion) |
IA rtPA |
Improved to NIHSS 7; ultimately no residual deficits |
Healthy infant delivered at term via SVD |
[43] |
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