Comorbid Mood Disorders
Mood disorders are common in patients with TBI, especially in those with combat-related trauma. These conditions, particularly depression and PTSD, have a significant cause-and-effect relationship with sleep disorders. Moreover, the presence of sleep disorders in patients with PTSD or depression is associated with a diminished response to therapy and greater symptoms. As such, it would appear that the combination of both a mood and sleep disorder in an individual with a TBI would portend worse outcomes. Rao and coworkers assessed 54 patients with closed head injuries for risk factors for the development of sleep disorders. The investigators found that anxiety disorders developing post-injury were more significant predictors of sleep disruption than pain, comorbid diseases, or medication adverse effects. Similarly, in a clinical study of individuals with TBI, Shekleton found that these patients had significantly more anxiety, depression, and sleep disruptions than controls.
Medscape Pulmonary Medicine © 2011
Cite this: Jacob F. Collen, Christopher J. Lettieri. Sleep Disorders in Traumatic Brain Injury - Medscape - May 24, 2011.