Targeted Therapy in Refractory Thyroid Cancer

Current Achievements and Limitations

Lucia Brilli; Furio Pacini

Disclosures

Future Oncol. 2011;7(5):657-668. 

In This Article

Combination Drugs Trials

Target therapies using drug combinations is an attractive new strategy to increase efficacy and to prevent or overcome resistance. Several examples of drug combination are currently under investigation but only in a few cases are preliminary results available, which are discussed in the following sections.

Everolimus & Sorafenib

Everolimus and sorafenib have been tested in patients with advanced metastatic DTC (Phase II).[109,110]

Temsirolimus

Temsirolimus (a specific inhibitor of mTOR) and sorafenib used in a Phase II trial in patients with radioactive iodine refractory thyroid cancer.[111]

Tipifarnib

Tipifarnib (a farnesyltransferase inhibitor, that prevents the activation of Ras oncogenes, inhibiting cell growth, inducing apoptosis and inhibiting angiogenesis) and sorafenib: this combination has been evaluated in a Phase I trial in patients with various advanced cancers. Among patients with thyroid cancer, the best response in DTC was one out of 15 (7%) PR, 13 out of 15 (86%) stable disease; in MTC patients: five out of ten (50%) PR, five out of ten (50%) stable disease.[57,112]

SU5416

SU5416 (a VEGFR protein TKI1/2), and paclitaxel were employed in a Phase I trial in recurrent, locally advanced or metastatic cancer of the head and neck.[113]

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