Role of α2-agonists in the Treatment of Acute Alcohol Withdrawal

Andrew J Muzyk PharmD; Jill A Fowler PharmD; Daryn K Norwood PharmD; Allison Chilipko PharmD


The Annals of Pharmacotherapy. 2011;45(5):649-657. 

In This Article

Data Sources

We performed an extensive English-language MEDLINE search (1966 to December 2010) to identify articles evaluating the efficacy and safety of α2-agonists for alcohol withdrawal. Search terms included alcohol withdrawal, delirium tremens, clonidine, dexmedetomidine, α2-agonist, norepinephrine, noradrenergic, and sympathetic overdrive. Case reports and clinical studies were evaluated for topic relevance and clinical applicability. Literature on the use of lofexidine in alcohol withdrawal was excluded from this review, as it is not available in the US.


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