Management of Peyronie's Disease in the Aging Male

Rany Shamloul; Anthony J Bella


Aging Health. 2011;7(1):65-78. 

In This Article

Clinical Manifestations

Peyronie's disease presents with penile pain, nodule or induration, penile curvature or shortening during erection and/or sexual dysfunction. Penile pain primarily occurs during erection, and usually resolves within 12–18 months of PD onset.[6] PD deformities vary, but may manifest as curvature, indentation, palpable plaque or nodule, hourglass narrowing, penile shortening (with or without curvature) or a combination (Figure 2). PD is most evident during an erection, as tunical compliance is compromised and the paired corpora cavernosa are unable to expand normally. Nearly half of men with PD have dorsal curvature; although lateral, ventral or a combination of curvatures may also occur.[17]

Erectile dysfunction is present in 20–50% of men with PD, and occurs owing to a deformity preventing coitus, flail penis (cavernous fibrosis or vascular compromise), performance anxiety (psychological), or impaired erections caused by veno-occlusive dysfunction. Patient and partner quality of life are significantly impacted, as men with PD are at increased risk of depression, lowered self-esteem and relationship difficulties, in addition to body-image issues and pain.[6] Psychological manifestations have been underelucidated traditionally by urologists and primary-care practitioners, and represent a significant aspect of the burden of PD.


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