Development of Vaccines Toward the Global Control and Eradication of Foot-and-mouth Disease

Luis L Rodriguez; Cyril G Gay

Disclosures

Expert Rev Vaccines. 2011;10(3):377-387. 

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Expert Commentary

Global control and eradication of FMD has been proposed for many years. Recently in the Paraguay declaration of 2009, the World Organization for Animal Health, the Food Agriculture Organization and other international agencies and numerous governments set the goal for global eradication of FMD by the year 2030.[201] Although such declarations are important and eradication seems within reach, particularly in regions where FMD is largely controlled by vaccination, in other regions, where FMD is rampant and FMD control competes with other basic needs such as food, human health and education, such an eradication goal seems unlikely. There is a clear need for alternative control methods, particularly vaccines that can address the major shortcomings of current and even upcoming vaccines. These fit-for-purpose vaccines accompanied by appropriate diagnostics and control strategies should address the needs of each region and particularly induce long-term immunity sufficient to break the endemic transmission cycles that currently maintain the virus circulating in these areas.[106] Since funding for such vaccines, diagnostics and control strategies is limited worldwide, it is important to leverage international capabilities into aligned efforts toward common achievable goals. Such an effort requires international alliances such as the Global Foot and Mouth Disease Research Alliance,[203] launched in 2003 as a worldwide association of animal research organizations, that are involved in combating FMD. Its aim is to build a global alliance of partners to generate and share knowledge – in a virtual FMD laboratory – to develop tools that can better combat the threat of the disease. Collaborative research is central to the fulfillment of FMD global eradication.

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