Bromocriptine: A Sympatholytic, D2-dopamine Agonist for the Treatment of Type 2 Diabetes

Ralph A. DeFronzo, MD


Diabetes Care. 2011;34(4):789-794. 

In This Article

Safety and Tolerability

In the Cycloset monotherapy and add-on to sulfonylurea trials,[29] side effects that occurred more commonly in Cycloset versus placebo were nausea (26 vs. 5%), asthenia (15 vs. 8%), constipation (11 vs. 4%), dizziness (11 vs. 6%), and rhinitis (8 vs. 5%). In general, these side effects were mild and transient. Thirteen percent of Cycloset-treated subjects withdrew because of adverse events compared with 3–5% of placebo-treated subjects (P < 0.01). There was no increase in serious adverse events in the Cycloset compared with placebo groups (2.4 vs. 4.3%, respectively). There was no difference in the incidence of hypoglycemia between the Cycloset and placebo-treated groups in any trial.


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