Options for the Management of Attention Deficit/Hyperactivity (ADHD)

Marcia L. Buck, Pharm.D., FCCP, FPPAG


Pediatr Pharm. 2011;17(3) 

In This Article


In 2008, a prodrug of dextroamphetamine, lisdexamfetamine (Vyvanse®), was introduced in the US.[13] The prodrug is inactive until hydrolyzed in the blood and liver to dextroamphetamine and the amino acid l-lysine.[1–3,13] The product was designed to reduce the potential for abuse, but also provides a prolonged duration of action (up to 13 hours in some patients). For patients unable to swallow the capsule whole, lisdexamfetamine capsules can be opened and the contents dissolved in water. The resulting solution should be ingested immediately and not stored for later use.


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