Options for the Management of Attention Deficit/Hyperactivity (ADHD)

Marcia L. Buck, Pharm.D., FCCP, FPPAG

Disclosures

Pediatr Pharm. 2011;17(3) 

In This Article

Methylphenidate OROS Tablets

In 2000, McNeil introduced Concerta®, a once-daily methylphenidate product using Alza's osmotic-controlled release oral delivery system (OROS®).[4] This technology had been used successfully for several other drugs, including nifedipine and doxazosin. The tablet has an outer coating of methylphenidate that is absorbed rapidly after ingestion, providing approximately 20% of the dose immediately.[1–6] After the coating has dissolved, penetration of gastric fluid through the semipermeable outer membrane expands an osmotic agent in the push layer of the core, causing it to slowly force the methylphenidate contained in the core out a laser-drilled opening in the tablet over 12 hours.

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