PCOS Forum

Research in Polycystic Ovary Syndrome Today and Tomorrow

Renato Pasquali; Elisabet Stener-Victorin; Bulent O. Yildiz; Antoni J. Duleba; Kathleen Hoeger; Helen Mason; Roy Homburg; Theresa Hickey; Steve Franks; Juha S. Tapanainen; Adam Balen; David H. Abbott; Evanthia Diamanti-Kandarakis; Richard S. Legro


Clin Endocrinol. 2011;74(4):424-433. 

In This Article

Intraovarian Regulation of Ovarian Morphology

Kit ligand (KL) is an intraovarian cytokine that promotes multiple aspects of folliculogenesis in animal models including primordial follicle activation, follicle growth and survival, stromal cell differentiation, and theca cell proliferation and androgen biosynthesis.[35] Perturbation of these biological processes occurs in PCO, particularly in anovulatory women with PCOS, in whom there is evidence for abnormal oocyte growth, increased follicle and stromal density, thecal hypertrophy, and increased thecal cell androgen biosynthesis. Therefore, KL may play a key role in the morphogenesis of PCO, particularly in women with PCOS. Androgen regulation of KL has been reported,[36] but the role of KL signalling, its regulation in human ovaries and its relevance to PCOS are currently unknown.


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