PCOS Forum

Research in Polycystic Ovary Syndrome Today and Tomorrow

Renato Pasquali; Elisabet Stener-Victorin; Bulent O. Yildiz; Antoni J. Duleba; Kathleen Hoeger; Helen Mason; Roy Homburg; Theresa Hickey; Steve Franks; Juha S. Tapanainen; Adam Balen; David H. Abbott; Evanthia Diamanti-Kandarakis; Richard S. Legro

Disclosures

Clin Endocrinol. 2011;74(4):424-433. 

In This Article

Is There a Broad Experimental Approach to PCOS?

Although it was beyond the scope of our meeting to formulate a unifying experimental approach to better understand and treat PCOS, the close interaction of basic and clinical scientists allowed speculation on future directions for research. The utilization of discovery 'Omic' technologies should identify new and unsuspected proteins and metabolic pathways that could lead to new treatments for the disorder. A recent mathematical review of microarray data in women with PCOS identified 504 protein nodes and 1048 interactions among them and theorized that there was a cell cycle protein in this network yet to be identified.[82]

Several genome-wide association studies devoted solely to PCOS are ongoing in the United States, Europe and Asia and should yield new candidate genes and proteins as intriguing (or baffling) as those discovered in other complex disorders such as type 2 diabetes. As discussed previously, a number of existing cell culture and animal models exist to identify pathways, pathophysiological perturbances and interventions that normalize signal transduction in these pathways. These in turn may eventually be tested in randomized trials, large and small, in affected women with PCOS. Thus, there is a potential beneficial cycle of bed to bench to bed studies (Fig. 1).

Figure 1.

Concept of bed to bench to bed research studies in PCOS.

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