Osteocalcin: An Endocrine Link Between Bone and Glucose Metabolism

Bu B Yeap


Expert Rev Endocrinol Metab. 2011;6(2):177-185. 

In This Article

Five-year View

Over the next 5 years, I anticipate that longitudinal studies will clarify whether TOC levels predict incidence of diabetes or cardiovascular events. Greater interest in assays for ucOC will facilitate important studies in determining whether associations of ucOC with specific outcomes are stronger than those of TOC. Studies will investigate whether associations of ucOC or TOC with glucose metabolism and cardiovascular risk are independent of other markers of bone turnover. The role of vitamin K agonists and antagonists in modulating carboxylation of osteocalcin will be explored in relation to the effects on glucose metabolism. In the laboratory, identification of a potential receptor for osteocalcin, and clarification of its pattern of expression in tissues, could attract intense interest. The relevance to humans of osteoclast-mediated bone resorption regulating production of ucOC, and thereby modulating insulin sensitivity, will be a continuing focus of research.


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