Febuxostat for Treatment of Chronic Gout

Charnelda L. Gray, Pharm.D., BCPS; Nafesa E. Walters-Smith, Pharm.D., BCPS

Disclosures

Am J Health Syst Pharm. 2011;68(5):389-398. 

In This Article

Clinical Efficacy

The therapeutic goals of uric-acid-lowering therapy are to prevent crystal formation and to promote crystal dissolution by maintaining the serum uric acid at ≤6 mg/dL or less, which is below the saturation point for monosodium urate monohydrate.[34] The ability of febuxostat to decrease serum uric acid production through selective inhibition of enzyme xanthine oxidase has been established in short-term Phase II and III clinical trials and long-term open-label studies.

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