Febuxostat for Treatment of Chronic Gout

Charnelda L. Gray, Pharm.D., BCPS; Nafesa E. Walters-Smith, Pharm.D., BCPS


Am J Health Syst Pharm. 2011;68(5):389-398. 

In This Article


In general, long-term uric-acid lowering therapy, such as allopurinol, probenecid, or febuxostat, may not be warranted in all patients but is most appropriate in patients with recurrent acute attacks, tophi, radiographic evidence of joint damage, and urate nephrolithiasis.[34] The average wholesale price for febuxostat 80- and 120-mg tablets is $162 per 30 tablets ($5.40 per unit).[42] Allopurinol and probenecid are currently available as generics, with prices of $0.24 per unit for allopurinol 100-mg tablets, $0.64 per unit for allopurinol 300-mg tablets, and $0.98 per unit for probenecid 500-mg tablets. Although the results of clinical trials suggest that febuxostat is more effective than allopurinol in lowering serum uric acid levels, its cost may limit its use to patients with renal impairment, those intolerant to allopurinol, and patients who do not achieve the targeted serum uric acid level while taking the maximum recommended dosage of allopurinol.


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