Abstract and Introduction
Low-grade fibromyxoid sarcoma (LGFMS) is a rare neoplasm commonly affecting young adults and typically arising in the somatic soft tissue of the proximal extremities. Its occurrence within the big toe is exceedingly rare. A 43-year-old man had surgery on a mass located in the big toe, which was first noted 6 months previously. Histological examination revealed LGFMS. One year after surgery, the patient is alive with no evidence of disease. Low-grade fibromyxoid sarcoma is a rare neoplasm that should be considered in the differential diagnosis of spindle cell neoplasms of the foot.
Low-grade fibromyxoid sarcoma (LGFMS) is a rare neoplasm that occurs primarily in young male adults. Although LGFMS has a deceptively benign histologic appearance, local recurrence and late metastases have frequently been reported. Diagnosis of LGFMS is still difficult because of its characteristic bland-looking histologic features that can be confused with other benign or low-grade fibromyxoid lesions.[1–4] It was recently recognized that most cases of LGFMS exhibit the FUS/CREB3L2 fusion gene, and that rare cases may display a variant FUS/CREB3L1 fusion gene.[5–7]
Low-grade fibromyxoid sarcoma typically affects deep soft tissues including the thigh, inguinal area, shoulder, axilla, perineum, neck, and buttock. It is rarely seen in the distal extremities, especially in fingers or toes. This paper reports a case of LGFMS arising in the big toe, and discusses the histological features and differential diagnosis.
South Med J. 2011;104(3):241-243. © 2011 Lippincott Williams & Wilkins
Cite this: Low-grade Fibromyxoid Sarcoma Arising in the Big Toe - Medscape - Mar 01, 2011.