Should There Be a Standard Therapy for Mantle Cell Lymphoma?

Mitchell R Smith

Disclosures

Future Oncol. 2011;7(2):227-237. 

In This Article

Allogeneic Stem Cell Transplant

Allogeneic SCTs are experimental for MCL. The use of nonmyeloablative approaches to reduce early mortality make this feasible in a higher proportion of patients, although their use generally remains limited to relapsed patients. Graft-versus-MCL effects as an immunotherapy is of potential benefit. Some small studies with interesting results require additional numbers and longer follow-up,[65,66] although there are some long-term disease-free survivors [101]. The use of allo-SCT to consolidate initial remission, in the hope of providing a plateau in survival, would be possible if we were able to reduce short-term mortality and identify a particularly high-risk MCL population that would benefit.

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