Precursors of Basal-like and Triple-negative Cancers
A group of high-grade DCIS lacking ER, PR and HER2, and expressing 'basal' markers has been identified.[101–107] However, it should be noted that its prevalence is lower than that of invasive triple-negative and basal-like breast cancers and that triple-negative and basal-like cancers often lack an overt in situ component. Whether this is the result of basal-like and triple-negative breast cancers progressing rapidly from DCIS to invasive cancer and/or obliterating the DCIS precursor from which they arose remains a matter of speculation.
The majority of invasive cancers developing in microglandular adenosis is of triple-negative phenotype[108–112] and show metaplastic elements or is of adenoid cystic morphology.[109–112] It has been recently shown that microglandular adenosis may be a nonobligate precursor of triple-negative and basal-like breast cancers.[108,113] A stepwise progression in the number of gross chromosomal changes from microglandular adenosis to invasive carcinoma has been observed. However, given the rarity of microglandular adenosis, it is unlikely to be the precursor lesion for most triple-negative cancers.
Mod Pathol. 2011;24(2):157-167. © 2011
Nature Publishing Group
Cite this: Basal-like and Triple-negative Breast Cancers - Medscape - Feb 01, 2011.