Can Inhaled Corticosteroids Prevent Asthma Exacerbations?

Dhananjay Desai; Salman Siddiqui; Christopher Brightling


Curr Opin Pulm Med. 2011;17(1):16-22. 

In This Article


The evidence that ICSs reduce asthma exacerbations is compelling and their use is recommended in all international guidelines. There is growing evidence that biomarker-directed therapy in severe asthma improves personalized healthcare and further reduces exacerbation frequency. Improvements in our understanding of the mechanisms of exacerbations are likely to identify new effective therapies, which again will require careful phenotyping of patients to identify responsive groups. While we await these developments, ICSs at current guideline recommended doses have good safety profiles and are likely to remain the mainstay of asthma treatment for the foreseeable future.


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