Depression and Diabetes — A Bad Combination

Steven Dubovsky, MD


Journal Watch. 2011;31(2) 

In This Article


Clearly, depression can exacerbate both diabetes mellitus and CVD by encouraging poor diet, inactivity, smoking, alcohol use, and nonadherence to medication regimens. In addition, both disorders have been linked to activation of proinflammatory cytokines (see JW Psychiatry Mar 29 2010 and Nov 27 2006), which can contribute to CVD. Whether amelioration of depression directly improves cardiovascular risk factors is unknown, but it seems likely to enhance patients' active involvement in treatment of both diabetes and CVD.


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