Can Higher Levels of HLA-G Improve Liver Transplant Outcome?

Ron Shapiro, MD


January 14, 2011

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Hi. My name is Ron Shapiro. I am a Transplant Surgeon at the University of Pittsburgh. Today, I want to talk to you about a very interesting study from Stanford[1] that looked at soluble human leukocyte antigen-G (HLA-G) in the retransplant recipient.

We have always known that the liver is a more tolerogenic organ than other solid organs in transplantation, and some of the explanation has been related to speculation that HLA-G is involved. The group from Stanford established that HLA-G levels in tolerant liver transplant recipients were substantially higher than in nontolerant patients or in patients with acute rejection. This would be an important marker and one that we need to explore in other solid-organ recipients, with a view toward seeing if we can promote tolerance in our recipients.

Thank you.