Clinical Significance of Vitamin D Deficiency in Primary Hyperparathyroidism, and Safety of Vitamin D Therapy

Nasser Mikhail, MD, MSc


South Med J. 2011;104(1):29-33. 

In This Article


In PHPT, vitamin D inadequacy is a common feature that is usually associated with advanced disease phenotype, at least at the biochemical level. In addition, vitamin D deficiency can lead to diagnostic confusion in patients presenting with high serum PTH, but normal calcium concentrations. Vitamin D therapy is indicated in patients with PHPT having serum levels of 25-OHD <20 ng/mL. Close monitoring of serum and urine calcium levels is essential, as limited data suggest that those levels may increase in some patients in response to vitamin D replacement therapy.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as: