Clinical Significance of Vitamin D Deficiency in Primary Hyperparathyroidism, and Safety of Vitamin D Therapy

Nasser Mikhail, MD, MSc

Disclosures

South Med J. 2011;104(1):29-33. 

In This Article

Conclusion

In PHPT, vitamin D inadequacy is a common feature that is usually associated with advanced disease phenotype, at least at the biochemical level. In addition, vitamin D deficiency can lead to diagnostic confusion in patients presenting with high serum PTH, but normal calcium concentrations. Vitamin D therapy is indicated in patients with PHPT having serum levels of 25-OHD <20 ng/mL. Close monitoring of serum and urine calcium levels is essential, as limited data suggest that those levels may increase in some patients in response to vitamin D replacement therapy.

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