|
Grey et al24
|
Tucci25
|
Isidro and Ruano26
|
Grubbs et al27
|
Kantorovich et al15
|
Design |
Prospective audit study |
Prospective audit study |
Prospective |
Retrospective, controlled |
Retrospective |
Follow-up |
12 mo |
34 wk |
12 mo |
6 mo |
12 mo |
Patient number and gender |
n = 25, 23 women |
n = 56, 37 women |
n = 27, 24 women |
n = 112, 87 women |
n = 5, gender not reported |
Mean age (yr) |
68 |
30 |
67 |
58 |
Not reported |
Regimen of vitamin D therapy |
Cholecalciferol (vitamin D3) 50,000 IU/wk for 1 mo, then 50,000 IU/mo for 12 mo |
Ergocalciferol (vitamin D2) 50,000 U/wk for 8 wk, followed by 800 U/day up to 100,000 U/mo to keep serum vitamin D ≥75 mmol/L (30 ng/mL) |
Calcifediol (25OH vitamin D) 480–960 IU/d |
Ergocalciferol (vitamin D2) 50,000 units two to three times/wk for four to 8 wk to keep serum vitamin D ≥75 mmol/L (30 ng/mL) |
Vitamin D2 50,000 U + 1000 mg elemental calcium twice/wk for 5 wk |
Mean serum levels of 25-OHD at baseline |
11 ng/mL |
14 ng/mL |
11 ng/mL |
18 ng/mL |
8 ng/mL |
Mean serum levels of 25-OHD after vitamin D therapy |
31 ng/mL after one year |
37 ng/mL after 34 wk |
28 ng/mL after 12 mo |
46 ng/mL after four to 8 wk |
20 ng/ml after 5 wk |
Mean serum levels of calcium at baseline |
10.8 mg/dL |
11 mg/dL |
10.8 mg/dL |
10.9 mg/dL |
10.1 mg/dL |
Mean serum levels of calcium after vitamin D therapy |
10.8 mg/dL |
10.8 mg/dL |
10.9 mg/dL |
10.7 mg/dL |
10.1 mg/dL |
Patients having increase in serum calcium levels |
Calcium increased in one patient from 10.5 to 11.3 mg/dL |
Calcium increased in two patients from 11.2 to 12.1 mg/dL, and from 11.3 to 12.2 mg/dL at 10 wk |
Calcium increased in two patients from 10.8 to 12.4 mg/dL, and from 10.8 to 12 mg/dL. Vitamin D therapy was discontinued in the two patients after 3 mo |
Calcium increased in six of 112 patients (5%) to a maximum levels of 11.7 mg/dL |
Calcium increased in one patient from 10.5 to 10.9 mg/dL |
Baseline mean serum levels of intact PTH |
138 pg/mL |
144 pg/mL |
188 pg/mL |
175 pg/mL |
107 pg/mL |
Serum levels of PTH after vitamin D therapy |
102 pg/mL (26% significant reduction, P < 0.004) |
133 pg/mL after (7% reduction, not statistically significant) |
162 pg/mL (14% reduction, not statistically significant) |
164 pg/mL (6% significant reduction, P < 0.01) |
104 pg/mL (3% reduction, not Statistically significant) |
Change in urine calcium after vitamin D therapy |
Two patients had urine calcium >400 mg/24 hr |
No significant change |
Significant increase in the mean value from 228 to 316 mg/24 hr |
Not reported |
Significant increase in mean urinary calcium/creatinine ratio from 0.06 to 0.24. Three of the five patients developed hypercalciuria (urinary calcium/creatinine ratio >0.160) |
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