Bronchial Provocation Testing: The Future

Sandra D. Anderson; John D. Brannan


Curr Opin Allergy Clin Immunol. 2011;11(1):46-52. 

In This Article


Methacholine is not as sensitive to identify BHR as previously thought and this may relate to presence of normal FEV1. A positive methacholine test result, in the absence of a positive response to an indirect stimulus may be an indicator of airway injury or remodelling rather than currently active asthma. Mannitol is more sensitive than exercise to identify BHR. Mannitol, however, is not as sensitive to identify exercise-induced bronchoconstriction as previously reported. Bronchial provocation using both a direct test and an indirect test may be required in some patients to confirm or exclude a diagnosis of asthma with certainty.


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