Renal Transplantation in HIV-Infected Patients

Ron Shapiro, MD


January 03, 2011

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Hi. My name is Ron Shapiro. I'm a transplant surgeon at the University of Pittsburgh [Pittsburgh, Pennsylvania]. Today I want to talk to you about a multicenter French study looking at kidney transplantation in HIV-positive recipients.[1] A great deal of interest in transplanting HIV-positive recipients has been reported in the United States, most recently in a multicenter National Institutes of Health-funded experience that was just published in The New England Journal of Medicine.[2]

Less has been reported from outside the United States, and this study from Paris is quite interesting, in that it was in 27 patients. It was associated with excellent patient graft survival at 1 and 2 years, and even more interestingly, it was associated with a very low incidence of acute cellular rejection. It is thus interesting to study and is, I believe, important because -- as many of you know -- HIV-positive patients with end-stage renal disease in the current era of highly active antiretroviral therapy (HAART) are unlikely to develop AIDS and are certainly unlikely to die of AIDS, but are in fact likely to die on dialysis. These successful outcomes are, I think, very interesting and worthy of study.

Thank you.


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