Management of Neuroendocrine Tumors: Current and Future Therapies

Kjell E Öberg


Expert Rev Endocrinol Metab. 2011;6(1):49-62. 

In This Article

Other Syndromes

Pancreatic NETs cause various well-established syndromes. For example, gastrinomas secrete gastrin and cause Zollinger-Ellison syndrome, which is characterized by peptic ulcers, diarrhea and abdominal pain. Glucagonomas produce excess glucagon that leads to hyperglycemia and is associated with diabetes mellitus and a typical skin rash, chronic necrolytic migratory erythema. Insulinomas cause hypoglycemia due to excess insulin, whilst VIPomas produce excess vasoactive intestinal peptide leading to Verner-Morrison syndrome with severe watery diarrhea (10–15 l/day) and flushing.


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