Lower Levels of IL-10 May Be Markers for Interstitial Fibrosis and Tubular Atrophy

Ron Shapiro, MD


December 22, 2010

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Hi. My name is Ron Shapiro. I'm a transplant surgeon at the University of Pittsburgh. Today I want to talk to you about an interesting article looking at cytokine gene profiling; specifically this was a study from Calgary looking at the impact of low levels of interleukin-10 in renal transplant patients.

As a group, patients with lower levels of interleukin-10 were more likely to develop interstitial fibrosis and tubular atrophy (IFTA), hallmarks of what we used to call chronic allograft nephropathy on kidney biopsies. We have always thought of high levels of interleukin-10 as perhaps being protective, although that has been somewhat controversial, but here there are some interesting data suggesting that low levels of interleukin-10 are perhaps a marker for patients who are more likely to develop problems related to chronic allograft nephropathy or what we call IFTA these days. I thought that this was an interesting analysis, and would suggest that you all take a good look at it.

Thank you.


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