Self-nanoemulsifying Drug Delivery Systems: Formulation Insights, Applications and Advances

Abhijit A Date; Neha Desai; Rahul Dixit; Mangal Nagarsenker

Disclosures

Nanomedicine. 2010;5(10) 

In This Article

Self-nanoemulsifying Drug Delivery Systems

Self-nanoemulsifying drug delivery systems (SNEDDS) are nanoemulsion preconcentrates or anhydrous forms of nanoemulsion. These systems are anhydrous isotropic mixtures of oil, surfactant(s) and drug, which, when introduced into aqueous phase under conditions of gentle agitation, spontaneously form O/W nanoemulsions (usually with globule size less than 200 nm).[40] In the body, the agitation required for formation of nanoemulsions is provided by digestive motility of the GI tract. SNEDDS can also contain coemulsifier or cosurfactant and/or solubilizer in order to facilitate nanoemulsification or improve the drug incorporation in SNEDDS.

Compared with ready-to-use nanoemulsions, SNEDDS can offer advantages such as:

  • Improved physical and/or chemical stability profile upon long-term storage;

  • Possibility of filling them into unit dosage forms, such as soft/hard gelatin or hydroxypropylmethylcellulose capsules (unlike ready-to-use nanoemulsions), which improves their commercial viability and patient compliance/acceptability;

  • No palatability-related issues, as SNEDDS can be filled into capsules.

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