Self-nanoemulsifying Drug Delivery Systems: Formulation Insights, Applications and Advances

Abhijit A Date; Neha Desai; Rahul Dixit; Mangal Nagarsenker

Disclosures

Nanomedicine. 2010;5(10) 

In This Article

Future Perspective

Research on SNEDDS technology has accelerated in the last 5 years and several reports have appeared in the literature. SNEDDS have primarily been explored for enhancement of bioavailability in oral drug delivery. The pH-catalyzed and solution-state degradation of drugs in SNEDDS needs to be evaluated. The conversion of SNEDDS to a solid state can reduce drug degradation but cannot eliminate it in many cases. Hence, it is important to identify microenvironment-modulation strategies for improving the stability of pH-sensitive drugs. Considerable investigations have been carried out to convert liquid SNEDDS to a solid dosage form such as tablets and pellets. However, there is a need to identify a suitable highly porous amphiphilic carrier that can convert liquid SNEDDS into a solid powder without significant increase in the volume or bulk density. The applications of SNEDDS in other routes of delivery apart from the oral route can be explored. The commercialization of SNEDDS technology would depend on the ability of drug delivery scientists to address these aspects of SNEDDS.

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