Self-nanoemulsifying Drug Delivery Systems: Formulation Insights, Applications and Advances

Abhijit A Date; Neha Desai; Rahul Dixit; Mangal Nagarsenker


Nanomedicine. 2010;5(10) 

In This Article


Drug discovery programs yield a large proportion of new chemical entities that are lipophilic and poorly soluble. Self-nanoemulsifying formulations have shown tremendous potential in improving the bioavailability of such therapeutic agents with limited aqueous solubility. The nanosize of these formulations is responsible for facilitating enhancement of drug dissolution and absorption, owing to the large surface area. The lipidic nature of these systems allows delivery of drugs to the lymphatic system. However, certain issues, such as drug–excipient interaction, oxidation of vegetable oils, toxicity and safety warrant attention during the development of SNEDDS. The amenability of converting SNEDDS into solid self-nanoemulsifying systems enables development into solid dosage form. Thus, the solid self-nanoemulsifying system can serve as platform technology for delivering poorly soluble drugs. Although a lot of research is being carried out in this area, other aspects, such as in vitro/in vivo correlation, need to be established.


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