Self-nanoemulsifying Drug Delivery Systems: Formulation Insights, Applications and Advances

Abhijit A Date; Neha Desai; Rahul Dixit; Mangal Nagarsenker

Disclosures

Nanomedicine. 2010;5(10) 

In This Article

Controlled-release SNEDDS

The self-nanoemulsifying system can also be employed to fabricate extended-release delivery systems for poorly soluble drugs. Patil et al. developed an extended-release felodipine self-nanoemulsifying system where Aerosil 200 was used as the gelling agent and the gelled SNEDDS were encased in hydrophobic Gelucire 43/01[113] Eutectic-based solid SNEDDS of Coenzyme Q10 was prepared using the tableting technique by Nazzal and Khan, where Kollidon® VA 64, Glucidex® IT 12, and Avicel® PH-112 were used.[114] This study demonstrated that a tablet dosage form could be manufactured to release a lipid formulation in a controlled-release pattern without the need for any complicated manufacturing techniques. Common processing parameters, such as amount of colloidal silicon dioxide, magnesium stearate, mixing time and compression force, have a profound effect on the release of lipid formulations from their solid carriers.

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