Risk of Morbidity in Contemporary Celiac Disease

Nina R Lewis; Geoffrey KT Holmes


Expert Rev Gastroenterol Hepatol. 2010;4(6):767-780. 

In This Article

Pulmonary Diseases

In a Scandinavian cohort of patients with cystic fibrosis, the prevalence of celiac disease was three-times greater than the general prevalence of celiac disease in Norway and Sweden.[173] Symptoms due to celiac disease will be alleviated by a gluten-free diet, so making this diagnosis is important and screening those with cystic fibrosis is recommended.[173] A three- to four-fold risk of TB occurred in celiac disease, and was seen in males and females and in those diagnosed with celiac disease above and below the age of 16 years[174] and confirms some earlier studies. However, among the 14,335 patients with celiac disease, only 24 had TB, so absolute numbers were small. It was considered that malnutrition and particularly vitamin D deficiency may be important in reducing the ability of patients to generate an appropriate immune response against Mycobacterium tuberculosis. A possible increased risk of venous thromboembolism among adult celiac patients may occur.[175] Celiac disease may be linked to sarcoid,[176,177] perhaps through common haplotypes.[178] Diffuse lung disease occurs in celiac disease. Fibrosing alveolitis, bird fancier's lung and farmer's lung are found, but the strength of these associations is not clear.


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