Risk of Morbidity in Contemporary Celiac Disease

Nina R Lewis; Geoffrey KT Holmes

Disclosures

Expert Rev Gastroenterol Hepatol. 2010;4(6):767-780. 

In This Article

Genetic Disorders

The prevalence of celiac disease is increased in some genetic disorders. Approximately 5% of children with Down syndrome were affected.[169] In total, six out of 63 children with Williams syndrome had celiac disease, compared with one in 184 of the student population, giving a highly significant difference.[170] The prevalence of celiac disease in Turner syndrome is 5–8%.[171,172] Patients with these syndromes often have gastrointestinal symptoms and short stature, and if due to associated celiac disease, may benefit from a gluten-free diet. Screening of these groups is recommended,[170,172] and use of HLA-DQ2 and HLA-DQ8 to exclude those who do not need to be screened because of the absence of these markers is also advocated.[169]

Comments

3090D553-9492-4563-8681-AD288FA52ACE
Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as:

processing....