Risk of Morbidity in Contemporary Celiac Disease

Nina R Lewis; Geoffrey KT Holmes


Expert Rev Gastroenterol Hepatol. 2010;4(6):767-780. 

In This Article

Genetic Disorders

The prevalence of celiac disease is increased in some genetic disorders. Approximately 5% of children with Down syndrome were affected.[169] In total, six out of 63 children with Williams syndrome had celiac disease, compared with one in 184 of the student population, giving a highly significant difference.[170] The prevalence of celiac disease in Turner syndrome is 5–8%.[171,172] Patients with these syndromes often have gastrointestinal symptoms and short stature, and if due to associated celiac disease, may benefit from a gluten-free diet. Screening of these groups is recommended,[170,172] and use of HLA-DQ2 and HLA-DQ8 to exclude those who do not need to be screened because of the absence of these markers is also advocated.[169]


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