Increased Renal Sodium Absorption by Inhibition of Prostaglandin Synthesis During Fasting in Healthy Man. A Possible Role of the Epithelial Sodium Channels

Thomas G Lauridsen; Henrik Vase; Jørn Starklint; Carolina C Graffe; Jesper N Bech; Søren Nielsen; Erling B Pedersen


BMC Nephrology. 2010;11 

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In conclusion, ibuprofen decreased urinary sodium excretion considerably in healthy man during fasting, a state with an increased prostaglandin synthesis. During the reduced prostaglandin synthesis u-ENaCβ was markedly increased. Our results suggest that prostaglandins have an important direct regulatory function on ENaC trafficking. During hypertonic saline infusion, angiotensin II and aldosterone tended to decrease in plasma and the natriuretic peptides increased, which presumably can be seen as compensatory phenomena to prevent extracellular fluid expansion. Surprisingly, ibuprofen also decreased urinary u-AQP2 both during 24 hours of fasting and during hypertonic saline infusion. This effect was not mediated via the vasopressin-c-AMP-axis, but may be mediated by the changes in the natriuretic peptide system and/or the angiotensin-aldosterone system.


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