In conclusion, ibuprofen decreased urinary sodium excretion considerably in healthy man during fasting, a state with an increased prostaglandin synthesis. During the reduced prostaglandin synthesis u-ENaCβ was markedly increased. Our results suggest that prostaglandins have an important direct regulatory function on ENaC trafficking. During hypertonic saline infusion, angiotensin II and aldosterone tended to decrease in plasma and the natriuretic peptides increased, which presumably can be seen as compensatory phenomena to prevent extracellular fluid expansion. Surprisingly, ibuprofen also decreased urinary u-AQP2 both during 24 hours of fasting and during hypertonic saline infusion. This effect was not mediated via the vasopressin-c-AMP-axis, but may be mediated by the changes in the natriuretic peptide system and/or the angiotensin-aldosterone system.
Clinical Trials Identifier: NCT00281762
We thank laboratory technicians Lisbeth Mikkelsen, Henriette Vorup Simonsen, Kirsten Nyborg and Anne Mette Ravn for skilful technical assistance and commitment, catering officer and the staff at the kitchen for making the diet, and The Hospital Pharmacy for randomizing and preparation of the study drug.
The trial was supported by grant from Ringkjobing County, Lundbeck Foundation and Hoerslev Foundation
All authors have made substantial contribution in designing the study and collection of data. They have all contributed in writing the manuscript and have approved the final version.
The authors declare that they have no competing interests.
BMC Nephrology. 2010;11 © 2010
BioMed Central, Ltd.
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Cite this: Increased Renal Sodium Absorption by Inhibition of Prostaglandin Synthesis During Fasting in Healthy Man. A Possible Role of the Epithelial Sodium Channels - Medscape - Nov 01, 2010.