Drug-induced Thrombocytopenia: Pediatric Cases from the Medical Literature

Imipramine

In 2009, Aksoy and colleagues reported an unusual case of immune-mediated DITP caused by imipramine.^[15] The patient, a 5-year-old boy was being treated for attention-deficit-hyperactivity disorder with imipramine 10 mg daily. At his one week follow-up, he was noted to have petechiae on both legs. A platelet count obtained at that time was 18,000/mm³. There were no other abnormalities. Increased megakaryocytes were noted on the bone marrow aspiration smear. Imipramine was discontinued and the patient was treated with methylprednisolone. Within a week, his platelet count had risen to 391,000/mm³. He recovered without sequelae.

Pediatr Pharm. 2010;16(11) © 2010 Children's Medical Center, University of Virginia

Cite this: Drug-induced Thrombocytopenia: Pediatric Cases from the Medical Literature - Medscape - Nov 01, 2010.