Common Variable Immunodeficiency at the End of a Prospering Decade: Towards Novel Gene Defects and Beyond

Hermann Eibel; Ulrich Salzer; Klaus Warnatz


Curr Opin Allergy Clin Immunol. 2010;10(6):526-533. 

In This Article


In summary, there is an increasing interest in CVID as a paradigm for a collection of heterogeneous immunodeficiencies leading to the same outcome of low concentrations and poor function of serum immunoglobulins. After tools for immunological characterization and classification were set up and the first genetic defect correlating with CVID was discovered in 2002/2003, the heterogeneity of CVID has been addressed in large cohorts by an improved immunological characterization and five additional gene defects are now published. Considering the progress in genetic mapping and sequencing technologies there are certainly more to come. The impact of genetics and improved immunological work up as booster for CVID research is nicely documented by the steadily increasing number of yearly publications in the field (Fig. 1), which will help to discover the still large unknown areas on the map of this exciting immunodeficiency.

Figure 1.

The figure indicates the increasing number of yearly publications on 'CVID' as detected by the online search


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