The function of AVP-c-AMP-AQP2 axis was abnormal in patients with an e-GFR between 15 and 60 ml/min. The ability to concentrate urine was decreased in renal insufficiency due to an impaired and reduced response in c-AMP and AQP2 to AVP, which was elevated in plasma, presumably as a compensatory phenomenon. The ability to dilute urine was deteriorated in renal insufficiency, presumably due to both a lack of suppression in AVP during water loading and a defect in the regulatory function of AVP on c-AMP with a secondarily up regulation of AQP2 water channels.
ClinicalTrials.Gov Identifier: NCT00313430
We thank the laboratory technicians in Department of Medical Research for skilful assistance in examining patients and doing laboratory analyses. The study was supported by a donation from The Free Masons in Holstebro at their 125 Years Anniversary, and by grants from Research Forum in Western Denmark and Ringkjoebing County.
EBP conceived of the study, participated in design, coordination and recruitment of subjects, had responsibility for the biochemical analyses, performed most of the statistical analysis, and drafted the manuscript. IT participated in design and coordination of the study, and performed a part of the statistical analysis. TGL participated in design, coordination of the study, recruitment of subjects, and the experimental procedures. All authors read and approved the final manuscript.
The authors declare that they have no competing interests.
BMC Nephrology. 2010;11(26) © 2010
BioMed Central, Ltd.
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Cite this: Abnormal Function of the Vasopressin-cyclic-AMP-aquaporin2 Axis During Urine Concentrating and Diluting in Patients with Reduced Renal Function. A Case Control Study - Medscape - Oct 05, 2010.