Abnormal Function of the Vasopressin-cyclic-AMP-aquaporin2 Axis During Urine Concentrating and Diluting in Patients with Reduced Renal Function. A Case Control Study

Erling B Pedersen; Ingrid M Thomsen; Thomas G Lauridsen


BMC Nephrology. 2010;11(26) 

In This Article


The function of AVP-c-AMP-AQP2 axis was abnormal in patients with an e-GFR between 15 and 60 ml/min. The ability to concentrate urine was decreased in renal insufficiency due to an impaired and reduced response in c-AMP and AQP2 to AVP, which was elevated in plasma, presumably as a compensatory phenomenon. The ability to dilute urine was deteriorated in renal insufficiency, presumably due to both a lack of suppression in AVP during water loading and a defect in the regulatory function of AVP on c-AMP with a secondarily up regulation of AQP2 water channels.


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